Unlockable - Costumes | |
| Ashley Special 1 | Beat the game once. |
| Ashley Special 2 | Beat the Separate Way. |
| Leon Special 1 | Beat the game once. |
| Leon Special 2 | Beat the Separate Way. |
Unlockable - Extra Weapons | |
| Handcannon | Get 5 stars rank in all Mercenaries stages with every characters. |
| Infinite Rocket Launcher | Beat the game once. |
| Matilda | Beat the game once. |
| P.R.L. 412 | Beat the game on Professional mode once. |
| Chicago Typewriter (main game) | Beat Separate Way once. |
| Chicago Typewriter (Separate Way) | Clear Assignment Ada. |
Unlockable - Mecenaries Characters | |
| Ada | Clear Village stage with 4 or more stars rank. |
| Krauser | Clear Castle stage with 4 or more stars rank. |
| Wesker | Clear Waterworld stage with 4 or more stars rank. |
| HUNK | Clear Military stage with 4 or more stars rank. |
Unlockable - Extras | |
| Mecenaries | Beat the game once. |
| Separate Way | Beat the game once. |
| Assignment Ada | Beat the game once. |
| Alternate Title Screen | Beat the game once. |
| Movie Browser | Beat the game once. |
| Professional Mode | Beat the game once on the Normal difficulty setting. |
