Unlockable - Unlockable characters |
| Raikov | Place spies in Western Wilderness before clearing the Guard House mission. Afterwards you should get a report of a handsome prisoner being held there. |
| Cunningham | Beat Cunningham on ANY difficulty by stamina kill and beat the game before January 1st 1971 in game. You get him after you make a new game. |
| Null | Kill Null by stamina kill or HP kill when you face him twice and beat the game. You get him after you make a new game. |
| Python | Kill Python by stamina kill. |
| Elisa | Get a Medic level of 80. |
| Major Zero | Have a MGS:DGN game save on your psp's memory stick. (Second Playthrough only) |
| Teliko | Have a MGA game save on your psp's memory stick. (Second Playthrough only) |
| Venus | Have a MGA 2 game save on your psp's mamory stick. (Second Playthrough only) |
| Para Medic | Contact her on the radio on the Comm Tower stage. She will later need to be resceud in the hospital stage. Place spies in the hospital. |
| Sigint | After Snake is captured and rescued you can contact Sigint on the radio at the Comm stage. He will need to be rescued in the town. |
| Gene | Recruit 200 soldiers and stamina kill Gene all in one playthrough. |
| Sokolov | Give the Saturn V blueprints to Sokolov |
| Ursula | Have a Medic level of over 80, with the second number as an odd number |
| Gene (EU Version) | Complete Boss Rush mode |
